When the same woman has a second baby with Rh-positive blood, the antibodies will destroy the red blood cells in the baby. Rho D immune globulin is given to these women during pregnancy or after delivery to prevent them from making antibodies.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Rho D immune globulin in children. It is not recommended for an infant with Rh-positive blood whose mother is Rh-negative.
Although appropriate studies on the relationship of age to the effects of Rho D immune globulin have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of Rho D immune globulin in the elderly.
However, elderly patients are more likely to have age-related heart, kidney, or liver problems, and might have conditions that require an adjustment in the dose for patients receiving Rho D immune globulin. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription over-the-counter [OTC] medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. This can lead to potential complications especially if you become pregnant with another Rh positive baby in the future because your immune system will mount an attack against those Rh positive red blood cells.
RhoGAM is the injection used to treat Rh incompatibility during pregnancy. If you test Rh positive, the shot isn't necessary. If you undergo chorionic villus sampling CVS or amniocentesis , or if you experience bleeding during pregnancy or any trauma where you could be exposed to fetal cells, your doctor may give you the RhoGAM shot at another point in your pregnancy.
What to Expect follows strict reporting guidelines and uses only credible sources, such as peer-reviewed studies, academic research institutions and highly respected health organizations. Learn how we keep our content accurate and up-to-date by reading our medical review and editorial policy. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff.
This educational content is not medical or diagnostic advice. Use of this site is subject to our terms of use and privacy policy. Registry Builder New. This can cause your baby to develop anemia , and in severe cases, result in miscarriage. Since you and your baby don't share circulation, there are only a few points during pregnancy that fetal blood can come into contact with maternal blood. Tami Prince, M. To prevent complications, "it is critical that an Rh-negative woman be treated with Rh immunoglobulin if bleeding occurs in order to prevent antibody formation," Dr.
Prince says. Luckily, there's an injection women can receive during pregnancy to counteract Rh incompatibility: the RhoGAM injection. RhoGAM is an injection made up of antibodies called immunoglobulin that help protect a fetus from its mother's antibodies.
According to the product website , "RhoGAM prevents the Rh-negative mother from making antibodies during her pregnancy. As long as the Rh-negative mother receives RhoGAM appropriately during every pregnancy, her babies are at very low risk of developing [anemia]. Sheila Chhutani, M. The RhoGam does not cross the placenta and will not harm the baby. But one shot in particular is typically administered under very specific circumstances: we will explore what RhoGAM is, the injection behind it, and why some surrogates are encouraged to get it during pregnancy.
RhoGAM, short for Rho D Immune Globulin , is the brand name of a sterile solution made from human blood plasma and given to Rh-negative women in the form of an injection. Rh, or Rhesus, is a protein on the surface of red blood cells that most people naturally have. If you have the protein, you are considered Rh-positive. If not, you are Rh-negative, a trait shared by 15 percent of the US population. When a gestational carrier who is Rh-negative receives a RhoGAM shot, she is preventing her blood system from potentially attacking the fetal blood.
There are two aspects to consider in potential differences between the surrogate and the infant's blood systems:. If the gestational carrier is Rh-negative, but the baby is Rh-positive, she could develop antibodies that attack and destroy Rh-positive blood. This may cause fetal anemia, which can develop into hydrops fetalis, a condition that leads to internal bleeding, shock, and heart and kidney failure.
Before the development of the RhoGAM medicine in the s, this condition alone led to the death of about 10, newborns annually and brain damage in others.
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